- A Case of Hepatocellular Carcinoma Exhibited over Partial Response after Hepatic Arterial Infusion Chemotherapy
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Chang Wook Park, Young Lan Kown, Yong Jin Kim, Yoon Jung Kim, Hye Jin Seo, Kyung In Lee, Eun Soo Kim, Byung Kook Jang, Woo Jin Jeong, Kyung Sik Park, Kwang Bum Jo, Jae Seok Hwang, Young Hwan Kim, Jung Hyuk Kwon
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Journal of the Korean Liver Cancer Study Group. 2010;10(1):40-43. Published online June 30, 2010
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- Hepatocellular carcinoma (HCC) is one of the cancers with poor prognosis. Especially potal vein invasion is a grave
prognostic indicator in the setting of HCC. There is currently no effective method for treatment of HCC with portal vein
invasion. A 61-year-old female patient was diagnosed a massive HCCs in both hepatic lobe with portal vein thrombosis,
based on computed tomography (CT) and increased tumor marker, α-fetoprotein. She was treated with intrahepatic arterial
CDDP (10 mg on 1~5 day), 5-FU (250mg on 1~5 day) and leukovorin (12mg on 1~5 day) infusion via percutaneously
implantable port system (PIPS) every 3 weeks, totally seven times. The patient was still living 6 months after first hepatic
arterial infusion chemotherapy (HAIC) and follow-up CT showed partial response with necrosis of HCCs. We report here
a case of advanced HCC with portal vein thrombosis that was effectively treated with HAIC via PIPS.
- A Case of Hepatocellular Carcinoma Presenting with Rib Metastasis
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Kyung In Lee, Young Lan Kwon, Yoon Jung Kim, Hye Jin Seo, Yong Jin Kim, Chang Wook Park, Eun Soo Kim, Byoung Kuk Jang, Woo Jin Chung, Kyung Sik Park, Kwang Bum Cho, Jae Seok Hwang, Jung Hyeok Kwon
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Journal of the Korean Liver Cancer Study Group. 2010;10(1):64-68. Published online June 30, 2010
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- Bone metastasis is not uncommon and shows poor survival in patients with hepatocellular carcinoma (HCC). We describe
a case of HCC presenting with rib metastasis in a 54-year-old man. In spite of radiotherapy for rib metastasis, pain was
sustained and size of lesions were increased. So we performd CT-guided percutaneous ethanol injection therapy (PEIT).
Whenever new metastatic bone lesions were detected, we have done PEIT. However, abdominal CT scan at 25th month after
diagnosis shows residual viable tumors in pelvic bone and multiple metastatic nodules in both lung. He is alive by taking
conservative management for 27 months after diagnosis.
- A Case of Curative Resection of Advanced Hepatocellular Carcinoma After Localized Concurrent Chemo-Radiation Therapy
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Jee Suk Kwon, Jeong Eun Lee, Woo Young Park, Kyung In Lee, Eun Soo Kim, Byoung Kuk Jang, Woo Jin Chung, Kyung Sik Park, Kwang Bum Cho, Jaeseok Hwang
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Journal of the Korean Liver Cancer Study Group. 2009;9(1):67-70. Published online June 30, 2009
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- Advanced hepatocellular carcinoma (HCC) with portal vein thrombosis is not suitable candidates for surgical treatment at
the most of diagnosis because of poor liver function, extensive tumor involvement of the liver, vascular involvement, and/or
intra/extrahepatic metastasis. We attempted localized concurrent chemo-radiation therapy (CCRT) in patients having locally
advanced HCC with left and main portal vein thrombosis. We report a case of locally advanced HCC patient who became
surgically resectable by downstaging after localized CCRT. Localized CCRT was performed with a total radiation dose of
5,040 cGy (180 cGy×28 times) and hepatic arterial infusion of 5-fluorouracil (5-FU, 250 mg/day) and cisplatin (10 mg/day)
for 5 days via implantable port system during the second and the fifth weeks of the radiotherapy. Marked contraction of HCC
was noted on follow up computerized tomography (CT) after localized CCRT, and subsequently surgical resection with
curative aim was performed. He was gave a additional transcatheter arterial chemoembolization (TACE) because follow up
CT revealed intrahepatic metastasis at subcapsular portion of right hepatic lobe after 3 months of operation. The patient is
in complete remission status without recurrence to date.
- A Case of Benign Hepatic Nodule Difficult to Differenciate from Hepatocellular Carcinoma
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Byoung Kuk Jang, Woo Jin Chung, Kyung Sik Park, Kwang Bum Cho, Jae Seok Hwang, Sung Hoon Ahn, Young Hwan Kim, Jung Hyeok Kwon, Yu Na Kang
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Journal of the Korean Liver Cancer Study Group. 2007;7(1):45-48. Published online June 30, 2007
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- Improved imaging techniques have led to increasing detection of hepatic nodules incidentally. In many cases, a
lesion that has been detected by imaging studies is not sufficiently characteristic, or there are other clinical
concern, so that an imaging guided percutaneous needle biopsy is performed for definitive diagnosis. But
sometimes, there are diagnostic difficulty due to limited diagnostic samples. We report a case of diagnosis to
benign nodule, but not confirmed specific disease, by repeated CT guided fine needle biopsy.
- A Case of Combined Hepatocellular and Cholangiocarcinoma
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Woo Jin Chung, Sang Hun Jeon, Dong Choon Kim, Ju Yup Lee, Kyung In Lee, Hye Jin Seo, Byung Kuk Jang, Kyung Sik Park, Kwang Bum Cho, Jae Seok Hwang, Sung Hoon Ahn, Ku Jeong Kang, Young Hoon Kim, Jung Hyeok Kweon, Young Hwan Kim, Yu Na Kang
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Journal of the Korean Liver Cancer Study Group. 2007;7(1):59-61. Published online June 30, 2007
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- A 51 years-old man who had postnecrotic liver cirrhosis due to chronic hepatitis B had elevated serum alpha
fetoprotein level. According to computed tomographic findings, about 2.4cm sized mass was noted at segment 7
and he underwent segmentectomy. After 9 months later, multicentric recurrence was detected at segment 5-6, So,
he underwent transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection therapy. After
22 months later, marginal recurrence was noted again at segment 6. So, he underwent 2nd TACE and he was
following up over 30 months until now.
- Two Cases of Advanced Hepatocellular Carcinoma Showing Good Response to Hepatic Arterial Infusion Therapy
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Byoung Kuk Jang, Woo Jin Chung, Kyung Sik Park, Kwang Byum Jo, Jae Seok Hwang, Sung Hoon Ahn, Young Hwan Kim, Jin Soo Choi, Jung Hyuk Kwun
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Journal of the Korean Liver Cancer Study Group. 2006;6(1):60-64. Published online June 30, 2006
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- Prognosis of advanced hepatocellular carcinoma (HCC) treated by conventional therapies has been considered
to be poor. Hepatic arterial infusion therapy (HAIT) has been tried for advanced hepatocellular carcinoma with
portal vein tumor thrombosis or ineffective response to other treatment. We report two cases of advanced HCC
showing good respense to transarterial chemoembolization and CT guided percutaneous ethanol injection therapy.
- Two Cases of Bone Metastasis of Hepatocellular Carcinoma without Intrahepatic Recurrence
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Byoung Kuk Jang, Woo Jin Chung, Kyung Sik Park, Kwang Bum Cho, Jae Seok Hwang, Sung Hoon Ahn, Young Hwan Kim, Jin Soo Choi, Jung Hyeok Kwon
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Journal of the Korean Liver Cancer Study Group. 2006;6(1):89-94. Published online June 30, 2006
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- Extrahepatic metastases of hepatocellular carcinoma (HCC) are now increasing due to prolonged survival.
Extrahepatic metastases of HCC frequently develop in patients with more advanced stage and sometimes occur
without intrahepatic recurrence. We report two cases bone metastasis of HCC without intrahepatic recurrence
after treatment.
- A Case of Early Multiple Recurrences After Hepatectomy with Lymph Node Dissection in Hepatocellular Carcinoma with Lymph Node Metastasis
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Byoung Kuk Jang, Ki Min Kwun, Woo Jin Jung, Kyung Sik Park, Kwang Byum Jo, Jae Suk Hwang, Seong Hoon Ahn, Ku Jung Kang, Jung Hyuk Kwun
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Journal of the Korean Liver Cancer Study Group. 2004;4(1):62-66. Published online June 30, 2004
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- A 52-year-old man who underwent left hepatectomy with lymph node dissection due to hepatocellular carcinoma with lymph node metastasis. After 5 months of surgery, multiple recurrences were founded throughout the liver, lung, bones and intraperitoneal lymph nodes. The patient died of liver failure after rupture of recurrent hepatic tumor. From our experience, we reaffirmed that the prognosis of patients with nodal metastasis from hepatocellular carcinoma was generally poor, even after hepatic resection with lymph node dissection was performed.
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THE KOREAN LIVER CANCER ASSOCIATION
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